Some common values such as AMH, estrogen and progesterone can be measured and reported in completely different units. The units used can depend on the study you’re reading, or whether an American or Canadian institution processed your test.

So make sure to inspect the unit that comes after the number (for example: pg/ML? ng/ML? pmol/L?), and convert numbers into the same unit system when you’re trying to draw comparisons. We find that EndMemo provides a very clean interface for your medical needs.

The post I’m researching test results & hormone levels, but some sources use different measurement units. How do I convert them? appeared first on Fertility.ca.

The most common reason for a low TSH is taking too much thyroid medication. If you aren’t taking medication of that kind, it could be a naturally low TSH — which, if chronic, is most often because of Graves’ disease.

You can confirm or refute this with:

1. A blood test for “thyroid receptor antibody”
2. A thyroid ultrasound

Now, if your doctor doesn’t think your low TSH is anything to worry about, should you get a second opinion?

Perhaps yes, if you have symptoms of hyperthyroidism now (like a racing resting heartbeat) — or, if a repeat TSH in 4-8 weeks is still low. Sometimes your TSH just rebalances itself, so no deeper testing is necessary.

I hope that’s helpful — sometimes just watching and waiting really is appropriate, even when trying to get pregnant.

The post My TSH is low. Should I be worried? What should I do? appeared first on Fertility.ca.

What can happen if you have hypothyroidism?

You can think of the action of thyroid hormone as revving up your body and keeping it functioning at the proper rate. Too little and things slow down, and too much causes things to go too fast. Common symptoms of hypothyroidism include fatigue, weight gain, constipation, loss of sex drive, hair loss, dry skin, loss of periods, and miscarriages.

What causes you to get hypothyroidism?

Most commonly hypothyroidism is a result of an autoimmune process (your immune system attacks your thyroid gland with antibodies) called Hashimoto’s thyroiditis. Other causes include surgery or radiation treatments.

How do we test for hypothyroidism?

The most sensitive way to track thyroid activity is indirectly, by measuring Thyroid Stimulating Hormone (TSH), a hormone that stimulates your thyroid to produce thyroid hormone. When thyroid function is low, the brain detects this and raises the TSH to stimulate the thyroid. A higher than normal TSH suggests that your body is detecting hypothyroidism.

What is a normal TSH level?

Traditionally, TSH levels from 0.5 to 5.0 were considered normal. Above 5, we would diagnose and treat for hypothyroidism. (If the patient doesn’t actually have any symptoms, we call it “subclinical hypothyroidism”).
More recently, some researchers suggest we should treat subclinical hypothyroidism when TSH is over 2.5. There is some controversy around this. When the TSH is elevated your doctor will often ask for additional tests to look for the antibodies that would indicate that this is the autoimmune form of hypothyroidism.

How can hypothyroidism affect fertility?

For starters, hypothyroidism can lead to irregular cycles. It also affects babies because they rely on their mother’s thyroid hormone levels for the first trimester because its thyroid is not fully functional until around 20 weeks of gestation. If you are hypothyroid early in the pregnancy, your baby is as well. This is clearly a problem when you have untreated overt hypothyroidism but it is debated how much of a problem is posed by subclinical hypothyroidism. Most physicians will err on the side of treatment for subclinical hypothyroidism when you are trying to become pregnant.

How is it treated?

Hypothyroidism is treated with a synthetic form of thyroid hormone called Levothyroxine. It can take some time to make sure the dose is correct and so often a repeat blood test will be done in 4-6 weeks. It takes about that long for the TSH to adjust to the Levothyroxine or for any change in the dose of this medication. Monitoring is important to make sure you are getting enough thyroid hormone and also to make sure you are not getting too much.
Levothyroxine is a synthetic hormone with few impurities, very few side effects and produces almost no allergic reactions.

Once a patient is pregnant we will often increase dosing as pregnancy hormone interacts with TSH. We check TSH levels for all of our pregnant patients. If you are taking Levothyroxine there is no harm in reminding us that you too may need to have your dose increased.

What is “natural” thyroid hormone and should you take it?

The main hormone secreted by your thyroid gland is T4 hormone. Your body will then convert this to T3 hormone, which is the more active form of thyroid hormone. Natural thyroid hormone is desiccated thyroid gland and contains T3 and T4. It may be dangerous as the levels are difficult to predict. Most endocrinologists prefer to give synthetic T4 and let your body decide how much to convert to T3.

More questions?
Ask us here! We want to help.

You can also visit www.thyroid.ca.

The post Hypothyroidism and Fertility appeared first on Fertility.ca.

My suspicion is that this comes down to two reasons. Financial, yes, but importantly, emotional: For all of us, the plan was to achieve pregnancy naturally. It is a difficult step to move the act of fertilization into the laboratory.

But, if it has been more than six months of trying naturally together, there are three situations in which IVF may make the most sense:

1. Sperm

Whenever male factor is present, couples may choose to try to maximize sperm quality. This could be done through lifestyle management, through vitamins to maximize sperm quality, through medication such as Clomid to maximize the stimulation of the testes, and through intrauterine insemination to deliver more sperm to the ends of the fallopian tubes.

But none of the above is as effective as doing IVF. This is because with IVF, we can bypass all concerns associated with count, motility, morphology, or obstructions related to previous vasectomy or a congenital absence of the vas. All are treated with a single procedure, by doing intracytoplasmic sperm injection, or ICSI. ICSI places the sperm into the eggs.

It is an extraordinarily effective treatment, as long as the sperm’s DNA can support a healthy embryo.

And so before doing IVF, you might consider getting a karyotype done to confirm normal genetics, and a DNA fragmentation assay of the sperm, if available, to ensure that the DNA being delivered is well packaged and likely to be easily handled by the eggs.

For these reasons, male factor subfertility may often be a serious frustration, but if sperm’s DNA quality can be confirmed, then your expectations for successful IVF can be very high.

2. Tubes

It’s rare that compromised fallopian tubes will be able to be reopened through a cannulation procedure, very rare. The reality is that IVF is a far more successful approach, because it simply bypasses the fallopian tubes. Pregnancy rates can often be superb for a couple facing a situation where eggs and sperm are of good quality, the uterine structure is healthy, and the maternal health is excellent. If it is just a mechanical issue – sperm could not reach the eggs – IVF is a bypass.

As noted, we can try cannulation, or sometimes, if tubes are only partially compromised, we will look to inseminations.

“Partial compromise” can be very difficult to diagnose. Imaging, such as sonohystogram and HSG (hysterosalpingogram) will routinely miss compromised tubes, and the gold standard of investigation – laparoscopy – is highly interventional and invasive. For that reason, we miss fallopian tube compromise with great frequency, and arguably the number one cause for unexplained infertility will prove to be tubal dysfunction. It is for that reason that unexplained infertility is often also well treated through IVF.

A major risk for tubal compromise is low-grade endometriosis, but any source of pelvic scarring, including pelvic inflammatory disease from a previous STD like Chlamydia, a ruptured appendix, or other bowel surgery, all are risk factors for tubal compromise.

3. High quantity of low quality eggs

This situation is more complex. Many couples, particularly when women are over thirty-five years, increasingly worry about egg quality.

On the face of it, IVF would not seem to be all that beneficial; simply placing a sperm inside the egg does not increase its quality. Ninety-three percent of first trimester losses are related to embryo quality, 90% of which come back to egg. So, egg quality is a serious concern in any fertility setting.

The advantage that IVF can provide is this: Numbers. With high-dose fertility drugs, instead of the two to four eggs we will often encourage people to have intercourse or inseminations with, we would be aiming for ten, fifteen or twenty eggs with IVF.

And so it is a numbers game: If egg quality is a concern, and egg quantity is high, then IVF has a superb chance of being more beneficial than any other therapy for the shear advantages that come when ten to twenty eggs are fertilized at a time. It is like one to two years of trying naturally all focused into a single cycle.

And so when is IVF less successful?

Arguably, IVF is less successful when none of the elements above are present: If egg quality is a potential concern, but egg quantity is low, with all other parameters being normal, then IVF is unlikely to be of great benefit. When the issue is related only to uterine structure or implantation, IVF is unlikely to be successful, and if the issue is related to the couple’s overall health, IVF is unlikely to be successful.

IVF, therefore, may be our gold standard of therapy, but it is not for everybody. Still, if any of the three diagnoses above apply to your situation, and it has been a number of months of trying with other means, then IVF may well be considered as a reasonable option.

The post 3 situations where you’ll want to consider IVF appeared first on Fertility.ca.

Sperm’s ability to fertilize an egg is dependant on healthy DNA. But some sperm are fragmented.

Healthy DNA is arranged in a double-helix spiral bound by cross-bonds resembling a ladder. DNA damage means the bridges become unstable or broken causing instability in the DNA ladder.

That instability is referred to as fragmentation or damage of the DNA. If there is a high amount, you’ll likely see a reduction in male fertility, poor embryo development and lower rates of implantation.

Scientific literature shows that the extent of DNA fragmentation has little relevance to the basic semen quality parameters (concentration, motility, morphology, etc.) For example, a “good” sperm sample with high concentration, motility and morphology doesn’t guarantee you’ll get pregnant if there’s poor DNA Fragmentation Index (DFI).

Why is DNA Fragmentation important in the assessment of male fertility?

The test (flow-cytometry or TUNEL assays) is used to count the number of sperm cells per sample that contain suboptimal, damaged or fragmented DNA.

What are the values and what do they mean?

DNA Fragmentation Index (DFI) is used to quantify DNA damage in the sperm. DFI is inversely related to sperm’s ability to fertilize an egg and produce a viable embryo. DFI of less than 15% in sample is considered optimal. DFI between 16-29% is considered to be good or fair fertility potential. Sperm with DFI over 30% is considered to have poor fertility potential. Although exceptions do exist, these percent ranges have been established based on numerous scientific publications over many years of research.

What does testing mean for our ability to conceive?

• More accurate assessment of semen sample quality
• May explain previous failed attempts to conceive
• Determine suitability for IUI versus IVF/ISCI
• Assessment of efficacy of medical intervention or treatment of infectious diseases to improve
• Ultimately improve fertility potential of the male partner

What are the causes of DNA damage?

We don’t yet know all of the factors that lead to DNA damage. Most common ones we do know are chemical/toxin exposure, heat exposure, varicocele, age, infection, smoking, alcohol, radiation or testicular cancer.

The post What is DNA Fragmentation? appeared first on Fertility.ca.

We cannot really comment on the necessity of the test. But we can say unequivocally: no procedure should hurt. With modern anaesthesia, there really is no excuse for it. For example, in your case, you could ask about misoprostol (to soften the cervix), Ativan (for you), and a local-freezing-spray for your cervix. The procedure itself should never stand in the way of your desire to become pregnant. Hope that helps.

The post What can I do about pain during procedures?  appeared first on Fertility.ca.

That said, while Betabase shows the broad range of normal, its numbers are also fallible: self-reporting can result in inaccuracies. Historically, this data has been collected by clinics, which keeps the numbers accurate and reliable…but the sample size quite small.

So which is better: traditional clinic data collection or self-reported online data collection? We don’t know, but our guess is neither is inherently better, just different. The information each individual patient is personally seeking will ultimately determine which data set is more valuable and enlightening, and until we know more about the differences or similarities between these data pools, it can’t hurt to look into both.

The post What’s Betabase.info and is it reliable? appeared first on Fertility.ca.

1. Oocyte (egg) quality

Implantation is more likely to happen when a healthy embryo is present, and the best predictor for a healthy embryo is a healthy egg. Egg quality is based on a number of factors.

2. Sperm quality

We now know that paternally imprinted DNA is disproportionately expressed in developing placental tissue. In other words, sperm quality matters a lot when it comes to implantation. For a successful pregnancy, sperm should have stable, well balanced DNA.

What you can do:

There are many ways that sperm quality can be maximized. Antioxidant vitamins are a popular intervention. We have more on sperm here and here.

3. Embryo quality

Embryo quality is a reflection of both egg and sperm. If you are doing an IVF cycle, embryo quality can be determined by grading systems. The embryos most likely to continue to develop will have 6, 7, or 8 cells by day 3 of development in the lab.

If you are considering a frozen embryo transfer (FET), embryo quality is also a reflection of the laboratory’s freezing-and-thawing success rates. In some labs, FET cycles have a pregnancy rate of one-quarter to one-half that of fresh cycles, but the rates vary by clinic and many of us are now seeing the same (and even higher) success rates with FET. Embryos may be frozen with the traditional slow-freeze protocols, but with the flash-freeze vitrification methods we are seeing better success rates.

Here’s what you can do:

Maximize egg and sperm quality before you start treatments.

Consider a repeat fresh IVF cycle instead of multiple frozen cycles.

4. The number of embryos transferred

There are some suggestions that embryos help each other to implant. In other words, the more embryos that you transfer, the greater the chance that each one will stick.

Be very careful with this one. The movement in our field is away from multiple-embryo-transfer, not towards it, because the risks associated with multiple pregnancy are very real. Some clinics even advocate for elective single embryo transfer. But if there are other impediments to implantation–say, embryo quality is a known concern–then our standard of care is to transfer multiple embryos in the hope that one will take.

We also find we have more success with blastocyst embryos transferred at day 5 rather than morula embryos transferred at day 3.

5. The woman’s overall health

An overall health screen tests many things, and usually includes thyroid function and prolactin levels.

Depending on your situation and family history, you may also be screened for other systemic diseases that can affect implantation. For example, we might look to rule out diabetes, autoimmune conditions such as elevated Natural Killer cells, a pre-disposition to hypercoagulability, markers for celiac disease…and many more.

If you and your immediate family are otherwise healthy, many of these tests are not routinely offered.

Here’s what you can do:

Eat well, exercise moderately, don’t smoke, and continue seeing your family doctor for annual check ups even when under active fertility care. If you have or suspect a specific medical condition, ask your doctor if further testing is warranted.

6. Shape of the uterus and fallopian tubes

Some women have an anterverted uterus, some women have a retroverted uterus. Both are fine: the terms simply refer to which direction your uterus tips. Of more importance, we need to confirm that the uterine cavity is a normal size and shape for implantation to be successful.

To check the structure of your uterine cavity, the gold standard of imaging is a 3-dimensional sonohysterogram. Hysteroscopy (surgery) is used when necessary for things like fundal polyps, impinging or submucosal fibroids, and/or a uterine septum extends 10mm or more.

The shape of your fallopian tubes should be confirmed by ultrasound, a hysterosalpingram, or (less often) surgery. We also screen for chlamydial antibodies, because a history of this infection can affect tubes. We know that dilated tubes (”hydrosalpinges”) may compromise implantation, and sometimes suggest that they’re surgically removed before IVF.

Here’s what you can do:

Make sure that you have all the imaging tests available to you updated before starting your treatments. If your doctor suggests uterine surgery, you may want to get a second opinion. But don’t be too hesitant: the surgery is often a day procedure, and the benefits can be profound.

7. Lining of the uterus

We look at the uterine lining itself, to judge whether or not implantation may be expected. The endometrial lining can be assessed in the following ways:

Appearance on the transvaginal ultrasound

An ideal lining will be at least 7mm thick on day of ovulation trigger (the day your HCG spikes). Ideally, it will also have a “triple line” appearance (an ultrasound finding that shows a good response to estrogen).

After ovulation, the endometrium compresses somewhat, and the triple-line pattern will be less distinct. These are normal findings.

Luteal endometrial biopsy

An endometrial biopsy is not part of every cycle, but it may be done in the luteal phase of a cycle before IVF, in an effort to confirm that the implantation window exists. Various markers for this implantation window have been identified, including histologic appearance and grading, specific findings seen only by electron microscopy, and the staining for various markers that are thought to be associated with implantation.

There are several tests which analyze endometrial biopsy further looking for markers of implantation. This is controversial, as it does not work as well as we would like, but some tests include Harvey Kliman’s Endometrial Function Test, the “E-tegreity Assay” for beta-3 integrin, and sending a biopsy specimen off for culture (this is most useful when intrauterine fluid is collecting and worries about infection persist).

We offer the EFT through our office in partnership with Dr. Kliman.

Here’s what you can do:

When endometrial thickness is low (the lining is never more than 6mm thick), you should talk to your fertility doctor, for management is highly individualized. Many authorities recommend a BMI of >18.5; a healthy lifestyle that involves no smoking and limited caffeine; and ask that you consider red meat to be part of your diet. Supplemental estrogen is regularly used and acupuncture may also be suggested. But again: you should really speak with your doctor.

If you have irregular cycles and a tendency towards a thick lining (>12mm), you might benefit from an endometrial biopsy to rule out hyperplasia.

Even if the EFT is limited, the very act of getting an endometrial biopsy may help with implantation. The proper studies have not yet been done to support this statement, but many smaller ones suggest that implantation may be boosted by as much as 20% in some cases.

8. Embryo transfer technique during IVF

In an IVF cycle, embryo(s) selected for transfer will be collected into about 0.020cc of fluid and inserted into the womb. The process of insertion is highly physician dependent: this means that it matters who does your embryo transfer. The following issues will be considered by your doctor:

(a) Transfer medications like progesterone, antibiotics, and steroids.

(b) Cervical preparation

(c) Use of a tenaculum

(d) Catheter type

(e) Ultrasound guidance

(f) Post transfer instructions

Here’s what you can do:

Work with a doctor and clinic that you really trust. Embryo transfer is very important. Some physicians even suggest doing a mock transfer prior to the IVF cycle itself. It has been our experience that the uterus is lying in a slightly different position every time. In other words, the mock transfer did not help as much as we would have hoped for. We now judge the value of a mock transfer on a case-by-base basis.

9. Luteal Support

We support the luteal (post ovulatory) uterine lining with progesterone whenever we are worried about natural progesterone levels. Progesterone may be taken orally, intramuscularly, vaginally, or rectally. Other medications that you may read about for the luteal phase, and into early pregnancy, include estrogen, ASA, dexamethasone, Fragmin, Lovenox, IVIG, HCG, and others. We are very cautious here: some of these medications have side effects that, in some circumstances, could be of real concern to you or your baby.

Here’s what you can do:

Definitely talk to your doctor. The medications that you take in the luteal phase, and into pregnancy, must be compatible with bringing a healthy child into this world. That said, the ideal balance will keep your endometrial lining stable. If you find that you consistently have your period before the planned pregnancy test day, your luteal support may need to be re-examined.

10. Lifestyle

You need to minimize caffeine, quit smoking, and avoid alcohol. Intercourse during the “two week wait”? We think it’s fine, but I would ask your doctor, as everyone has a different opinion on this subject.

Conclusions

To be successful, your clinic must focus on implantation. Many protocols and techniques are well standardized across fertility clinics, but implantation standards are not. Because of this, there are great differences in implantation success rates across both clinics and doctors. We hope this article will help shed light on some of the complications and what you can do to help achieve a successful implantation.

The post How do I improve my chances for embryo implantation? appeared first on Fertility.ca.

It holds great promise for maximizing pregnancy rates. Most IVF failures can be attributed back to embryo quality.

Is PGS right for you? Perhaps, but it’s a highly personal choice. It depends a lot on your circumstances and needs to be explored with your doctor.

PGS is expensive and complicated. Neither of these things are great to hear, of course, but the promise inherent in this level of testing is profound and, for some couples, it can be an extremely beneficial solution.

Why is it so difficult? To understand the science, I recommend starting with www.chromosome-screening.org. The short version is, the process is a part of IVF.

As you know, IVF is when your eggs are retrieved and inside a laboratory introduced to sperm. Some days later, the fertilized eggs are placed back into the womb. Before that happens, PGS can be done.

To do PGS, we remove one or more cells from the embryo. These cells are then analyzed in the laboratory or they’re shipped to an external lab.  We look at the number of chromosomes that those cells carry. The idea is, that the cells accurately represent the embryo about to be implanted.

There are two kinds of lab analysis done on the cells: The laboratory can look for specific and known genetic diseases or can count the number of chromosomes.

Most people choose to count chromosomes. Most people aren’t looking for any specific disease because both partners aren’t predisposed to any diseases that are inheritable. What they’re looking for is to find out if their embryo is going to be of sufficient quality to be consistent with an ongoing pregnancy.

The most common reason that embryos are not healthy is something called aneuploidy – that means the embryo has too many or too few chromosomes. PGS checks to make sure the embryo has the correct number of chromosomes or anything else that would be abnormal or not suitable for transfer.

PGS is not all that new but the techniques involved have been changing over time.

One aspect that has not changed – you will need to do ICSI and assisted hatching as part of the process. ICSI is the placement of the sperm into the eggs, and it is necessary rather than traditional fertilization (where many sperm are placed around the egg), as with traditional fertilization there are going to be extra sperm stuck to the edge of the zona pellucida (egg shell). That means when the biopsy is done, an extra sperm could accidentally come along with the cell and the test will appear to be abnormal when, in fact, the cells were just fine. Doing ICSI, where we place the sperm into the egg, negates that risk.

Assisted hatching is where a laser penetrates the zona pellucida, at least partially in this case, so that the biopsy needle can be placed against the cells for removal.

Before PGS is even started, you are looking at the costs and complications implicit in IVF with ICSI and assisted hatching. But there are other expenses too. Most laboratories will charge a biopsy fee, the lab will also charge a diagnostic fee for the genetic testing and there can be some shipping charges when external labs are used.

Are the added expenses worth it? Well, in select circumstances, absolutely! If the technology can deliver on its promise, I’m willing to guess most of our patients would be more than happy. After all, many couples who have completed IVF without success can become frustrated by the apparent transfer of high-quality embryos into a healthy woman and still no pregnancy.

This happens because many so-called healthy-looking embryos, in fact, are aneuploid. Depending on the age group, only 30%-70% of apparently healthy, day-five embryos are, in fact, normal (and the ratio is even less for day-three embryos). Any technique that allows us to find the best embryo could be highly advantageous.

Historically, we have looked at cell number and the relative fragmentation of embryos to guess at an embryo most likely to be consistent with ongoing pregnancy. In more recent years, many labs strongly favour growing embryos to the blastocyst stage, which is five days of growth in the lab, to further differentiate the best-growing embryos. Finally, some laboratories are using “embryo scopes”, camera systems to allow constant visualization of the developing embryo. Huge amounts of data are being generated with such techniques, though it is difficult to say, of all this data, which of it is actually useful to predict who is going to have a baby.

And there’s the appeal of PGS: It gets right to the heart of the matter as we confirm whether or not there are the right number of chromosomes to be consistent with an ongoing pregnancy.

It is not that a euploid embryo is guaranteed to result in pregnancy, but some labs are reporting pregnancy rates in the range of 80% when euploid embryos are transferred. So, this is not a guarantee, but a far higher pregnancy rate than any other therapeutic approach to date.

But of note, I also mention the technical complications.

The chief amongst the complications are this: The biopsy and embryo manipulation.

Does the biopsy harm embryos? It may: There are some data suggesting embryos biopsied on day three do not fare as well as those biopsied on day five. Like any ongoing scientific processes, there remains debate on this point, but at this time, based on what information is available right now, I believe day-five biopsy makes the most sense. I may have to change my mind again in the future, the subject really is changing that quickly!

Though the day-five biopsy appears to be safe – cells are taken from the outer trophectoderm (cells that will eventually become the placenta) rather than from the inner cell mass (cells that will become the baby) – the challenge is deciding how best to handle the embryo from that point forward. There is going to be, after all, a waiting period while we look to the results of the PGS. This can be as short as twenty-four hours, or up to a week, depending on how the technique is done; but it necessitates for a day-five biopsy, either day six embryo transfer, or a freeze-all technique. Freeze-all meaning the embryos are frozen to be transferred in a future cycle (this will also add to the expense).

So, which is better? A day-six transfer or vitrification and transfer on a future cycle? I favour the latter, but again, this is lab dependent and you can get various opinions depending on which clinicians you speak to and the latest paper on the subject.

Lastly: The results that come from the laboratories regarding PGS are not always as reliable as we would like. There are some reports of embryos being retested and having completely different results than they did the first time around. Could this happen to you? Well, yes, it could and it is partly a limitation of the nature of the process: We are biopsying so few cells. This has to be contrasted with an amniocentesis, for example, done at sixteen weeks of pregnancy when literally hundreds of cells could be tested at a single time. It is much more accurate and you will find that even as PGS purportedly can rule out, for example Down’s Syndrome, you will be asked to have a definitive test later in pregnancy, regardless. PGS cannot be and is not definitive.

I like to write articles that discuss complicated subjects in transparent and easy-to-understand ways. PGS is a topic that is changing, at the information becomes more settled, I will continue to post information that I feel will be useful to a wider population.

At this time, the best I can say is that an educated conversation with your clinician is going to provide you the best sense for whether PGS is going to be helpful to you. That said, if you do not have confidence that you can generate a good number of blastocysts that PGS probably is not going to be helpful. After all, it is a sorting mechanism, and if you only have one or two embryos for transfer, sorting is not required. Careful transfer of your embryos may be all that is necessary.

The post Will pre-implantation genetic screening improve my IVF chances? appeared first on Fertility.ca.

But when you have a good ovarian reserve, you most likely will have some good quality eggs in there too.

You were born with millions of immature eggs.

Most of the immature eggs will be housed in microscopic follicles (small baskets of cells) that will lie quietly for months and years at a time. But every cycle during your fertile years, there will be some follicles that are primed to grow. These primed follicles are known as antral follicles.

Ideally, you will have a good-sized pool of these antral follicles each month.

Why is it so important to have a good-sized pool of antral follicles?

Actually, if you are trying to get pregnant naturally, ovarian reserve doesn’t matter too much. After all, up until menopause, your body will generally find 1 egg a month from the pool to mature and ovulate. I’m not saying ovarian reserve doesn’t matter with natural cycles, but we have all seen natural conceptions in women who have very low reserves.

If you are looking to to access fertility treatments, a good ovarian reserve is extremely helpful.

For example, in IVF, we find our best pregnancy rates occur when we generate 3-5 high quality embryos. The best predictor for this outcome is 10-15 eggs at retrieval. (It is possible to have 3 good embryos from 3 eggs, but less likely). And the best predictor for 10-15 eggs is a good ovarian reserve.

Tests of Ovarian Reserve

Antral Follicle Count (AFC)

The AFC is an ultrasound test. The u/s tech counts your antral follicles. The ideal AFC is 15-20 over the two ovaries. If your AFC is <10, your ovarian reserve may be low (assuming the tech is counting accurately).

As a test, AFC is very much technician-dependent: not every ultrasonographer can measure AFC well, and there tends to be a lot of inter- and intra-observer variability (i.e. everyone measures a different number). If you are a bit gassy (or a bit overweight), it can be difficult.

Our newest 3D ultrasound machines have the ability to record AFC’s automatically. However, the technology isn’t perfect, and we still prefer the accuracy of our clinical team to that of the computer.
Anti Mullerian Hormone (AMH)

AMH is a newer blood test, and in my opinion, the most accurate test of ovarian reserve. AMH is a hormone released by cells that are involved with the growth of antral follicles. AMH levels correlate with the number of active antral follicles present; the higher the antral follicle count, the higher the AMH levels. I trust it more than AFC, because it seems to correlate with the number of active follicles.

AMH can be tested through a regular blood test. It can be drawn during any day of the menstrual cycle whether or not you are on the birth control pill. In my opinion, AMH is the single most helpful test for women looking to understand their own fertility.

If you get an unusual number, it is reasonable to repeat the test. AMH can be difficult to process in the lab, so the occasional incorrect number will be generated. Ask to do it again if you are making important decisions based on AMH.

Follicle-stimulating Hormone (FSH)

FSH is a blood test, and is the traditional test of ovarian reserve, perhaps because it was more accurate than ultrasounds used to be. These days, ultrasounds are incredibly accurate, and AMH has taken over as the more accurate blood test.

FSH is the hormone that drives your antral follicles to grow.

If you have a good ovarian reserve, your body doesn’t need to make very much FSH to start the process of egg maturation. A number less than 10 IU/L is good; less than 8 is ideal. Greater than 12 is a worry. FSH levels change month-to-month, as the number of antral follicles change.

FSH levels are brought lower by the presence of estrogen, so your FSH level is only an accurate indicator of your ovarian reserve when Estradiol levels are <200pmol/l. Estrogen is lowest on day 3 of the cycle, which is why we usually measure FSH on day 3.

The main tests of ovarian reserve used to be day 3 FSH, but today we prefer antral follicle count studies and AMH to guide our care.Ovarian reserve is not the same thing as egg quality, but the two can be related. Women can achieve healthy pregnancies with a low ovarian reserve. Tests of ovarian reserve are important, but they are not your only measurement of future success. They are, however, a very helpful guide to optimizing and personalizing your fertility treatments.

The post What’s the difference between my ovarian reserve and egg quality? appeared first on Fertility.ca.